Cyclooxygenase products and atherosclerosis
نویسندگان
چکیده
منابع مشابه
Cyclooxygenase-2 and atherosclerosis: friend or foe?
Atherosclerosis, manifested by heart disease, stroke, and peripheral vascular disease, remains the leading cause of morbidity and mortality in industrialized countries despite aggressive vascular intervention and myriad blood pressureand lipid-lowering agents. Over the past decade, however, our understanding of atherogenesis has evolved from one of occlusive lipid accumulation to one of chronic...
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Intermittent hypoxia, the main stimulus of obstructive sleep apnoea (OSA), induces inflammation, leading to early atherosclerosis. Whether the cyclooxygenase (COX) pathway contributes to intermittent hypoxia-induced atherosclerosis remains to be determined. We studied the effects of 8-weeks of intermittent hypoxia exposure on COX-pathway gene expression and atherosclerosis, and the influence of...
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AIMS The risk of adverse cardiovascular events in humans is increased with chronic use of cyclooxygenase-2 (COX-2) inhibitors. However, the role of COX-2 in animal models of cardiovascular disease has been controversial. In humans and animal models, cardiovascular disease is increased by bacterial infection of the supporting tissue of the teeth, a condition known as periodontal disease. Periodo...
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There is increasing clinical evidence that phospholipid oxidation products (Ox-PL) play a role in atherosclerosis. This review focuses on the mechanisms by which Ox-PL interact with endothelial cells, monocyte/macrophages, platelets, smooth muscle cells, and HDL to promote atherogenesis. In the past few years major progress has been made in identifying these mechanisms. It has been recognized t...
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ژورنال
عنوان ژورنال: Drug Discovery Today: Therapeutic Strategies
سال: 2008
ISSN: 1740-6773
DOI: 10.1016/j.ddstr.2008.05.006